@Mike, see if the dealer can get you BSFC numbers. The engine manufacturers used to put them in the brochures, but stopped for some reason. They'll tell the tale.
Theoretically, the DD15 has the advantage of the compound turbo recouping otherwise lost exhaust energy. But who knows if that overcomes the inherent advantages of a smaller, lighter engine.
We're running DD13 because we were having so many issues with the ISX. The DD15 wasn't even an option for us, it won't clear the frame rails in these low rider chassis. So it never even got looked at.
What are the megas running in the Cascadia, and why? You might find your answer there, too.