If you have an opportunity to make 68-72k a year I would recommend going for it.
The only ones making anywhere close to that here are the .46cpm shuttle drivers, but that position is being phased out.
Actually the job is still there, but has been reclassified at a lower rate(.415). It is now called combo, which is a catch all term allowing them to work a driver on the dock, in the city or line haul.
According to the Averitt/Careers web site, there are no openings in SC, but it may not be current.
It does say there are immediate openings for combo drivers in Lawrenceville.(They call it Norcross for some reason)
As far as weekends for TL regional driver, my experience was generally late Friday to late Sunday, occasionally leave Monday if I brought a short load home.
Come dragging in on Saturday sometimes. But I can honestly say I never missed a weekend in just over three years.
Moving into something else is mostly a matter of location. It took me three years to get this dedicated gig. And that was only because the guy over me in seniority declined, not wanting to go up north every week.
I haul parts for Mercedes-Benz, working four on/three off.
Unlike where you live, there is very little opportunity here as far as quality driving jobs. I live three miles from Averitt yard and plan on retiring here. Nearest Estes yard I could run out of is Atlanta, 140 miles.
Maybe find something in Columbia, but that's still 80 miles.
I like it here very much, but not going to bs you. I think you could do better with the other choices you mentioned.