I don't worry about it, generally. I will start the truck every few hours when temps get below -10F. Till then, I just treat fuel and don't worry about it. I stay in upper tier of the U.S. all year round. MI, WI, MN, etc. I have used bio blends from 2% to 15% for over 5 years and have had not issues. Occasionally a more frequent filter change in the winter. My Davco filter unit has a heater in it for cold fuel.
I concern myself more with keeping batteries up, oil flow in the engine on a cold start, etc. When temps get into below 0F territory, I will run a portable generator, which is mounted on the frame rail, that is plugged into an oil pan heater and a Xantrex inverter charger. The Xantex keeps the batteries at full charge and the pan heater keeps the oil nice and warm. The heat rises out of the pan and heats the lower part of the block. have never had a cold start problem doing this. The generator uses a shade over 1 gallon in 10 hrs. Pretty cost effective.
When at home, plug in Xantrex, block heater, and pan heater.
If one wants the ultimate cold weather setup.. a Webasto or Espar diesel fired (or a dedicated tank with kerosene for EXTREME cold) coolant heater combined with Arctic Fox fuel tank heaters. The coolant heater will have the coolant in an engine up to 120F in one hour. As it cycles the coolant, it can also cycle warm coolant thru the Arctic Fox fuel tank heaters.